![]() ![]() All-cause and cardiovascular mortality differed significantly between the clusters.Ĭonclusions: We identified four phenotypic subgroups of CAD bearing distinct demographic and biochemical characteristics with differences in prognosis, which may indicate multiple disease entities currently summarized as CAD.Ĭoronary artery disease (CAD) is a leading cause of death worldwide ( 1). Cluster four with high-grade stenoses throughout had the oldest patients with the highest overall cardiovascular risk. Cluster three with predominant proximal LAD stenosis frequently presented with acute coronary syndrome and elevated troponin levels. Patients in cluster two exhibiting high-grade stenosis of the proximal RCA had a high prevalence of the metabolic syndrome, and showed the highest levels of inflammatory biomarkers. Results: Four clusters were identified: cluster one lacking critical stenoses comprised the highest percentage of women with the lowest cardiovascular risk. Clusters were independently confirmed in 3,129 patients from the LURIC study. Methods: In a cohort of 4,344 patients undergoing coronary angiography at Heidelberg University Hospital between 20, cluster analysis of angiographic reports identified subgroups with similar patterns of spatial distribution of high-grade stenoses. We wish to examine whether coronary angiography allows to identify distinct CAD phenotypes associated with major risk factors and differences in prognosis. Commonly, CAD is considered as a single disease entity. 6Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germanyīackground and Aims: The roles of multiple risk factors of coronary artery disease (CAD) are well established.5Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.4Medical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.3Department of Cardiology and Stroke Centre, Rottal-Inn Kliniken, Eggenfelden, Germany.2German Centre for Cardiovascular Research (DZHK) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.1Department of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany. ![]() Kleber 4 Graciela Delgado 4 Winfried März 4,5,6 Hugo A. Krohn 1,2 † Y Nhi Nguyen 1,2 † Mohammadreza Akhavanpoor 3 Christian Erbel 1,2 Gabriele Domschke 1,2 Fabian Linden 1,2 Marcus E. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |